The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses is mainly transmitted through respiratory droplets. Notably, some coronavirus disease 2019 (COVID-19) patients have ocular manifestations, including conjunctival hyperaemia, chemosis, epiphora, and increased secretions. However, the association between SARS-CoV-2 and ocular surface diseases is poorly described. Between May 2020 and March 2021, a total of 2, 0157 participants from six districts of China were enrolled. Serum samples were tested for immunoglobulin G and M (IgG and IgM) antibodies against the SARS-CoV-2 spike protein and nucleoprotein using magnetic chemiluminescence enzyme immunoassays. Throat swabs were tested for SARS-CoV-2 RNA using RT-PCR assays in a designated virology laboratory. Fisher exact, χ 2 test, and logistic regression analysis were performed. Of 2, 0157 serum samples tested, 1, 755 (8.71%) were from ocular surface diseases, 1, 2550 (62.26%) from no-ocular surface diseases (ocular diseases except ocular surface diseases), 5, 852 (29.03%) from no-ocular diseases. SARS-CoV-2 prevalence for the combined measure was 0.90% (182/2, 0157). Seroprevalence of SARS-CoV-2 was significantly (p<0.05) higher in the population with ocular surface diseases (2.28%, 40/1755) compared with no-ocular surface diseases (0.70%, 88/1, 2550), and no-ocular diseases (0.92%, 54/5, 852). Similar results were also observed with respect to sex, age, time, and districts. Logistic regression analyses revealed that ocular surface diseases [ocular surface diseases vs. no-ocular diseases (p=0.001, OR =1.467, 95% CI=1.174-1.834); ocular surface diseases vs. no-ocular surface diseases (p<0.001, OR =2.170, 95% CI=1.434-3.284)] were associated with increased risk of susceptible to SARS-CoV-2 infection. In a word, there was a significant association between ocular surface disease and SARS-CoV-2 infection. Therefore, increasing awareness of eye protection during the pandemic is necessary, especially for individuals with ocular surface diseases.
【저자키워드】 Seroprevalence, Immunoglobulin G, cross-sectional study, SARS- CoV-2, COVID - 19, immunoglobulin M, ocular surface diseases, 【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, pandemic, Diseases, antibody, SARS-COV-2 infection, Sex, virus, Spike protein, Laboratory, Prevalence, immunoassays, China, Immunoglobulin, Patient, Ocular surface, Manifestations, age, SARS-CoV-2 RNA, Swab, disease, chemiluminescence, RT-PCR assay, association, IgG and IgM, Respiratory droplets, acute respiratory syndrome, Logistic regression analysis, increased risk, enzyme, individual, participant, Fisher, serum sample, conjunctival, ocular, susceptible, enrolled, tested, described, performed, significantly, transmitted, Throat, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, surface, District,