Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N -glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N -glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in acute immune responses. In severe cases, a low level of IgG sialylation contributes to the ADCC-regulated enhancement of inflammatory cytokines. The decreases in sialylation and galactosylation play a role in COVID-19 pathogenesis via the activation of the lectin-initiated alternative complement pathway. IgG N -glycosylation underlines the complex clinical phenotypes of SARS-CoV-2 infection.
【저자키워드】 COVID-19, SARS-CoV-2, IgG, glycosylation, case-control study, 【초록키워드】 Coronavirus disease 2019, SARS-COV-2 infection, Health, COVID-19 pathogenesis, severity of COVID-19, immune responses, severe cases, age, ADCC, Inflammatory cytokines, clinical phenotype, Interaction, COVID-19 patient, Complement pathway, Activation, profile, complex, healthy controls, previous study, cell cytotoxicity, approach, decrease, analyzed, recruited, conducted, changes in, contribute, suggested, hydrophilic, healthy individual, N -glycosylation, upregulate, 【제목키워드】 Immunoglobulin G, profile,