Background: BNT162b2 and mRNA-1273 are the two recently approved mRNA-based vaccines against COVID-19 which has shown excellent safety and efficacy. Preliminary data about specific and neutralizing antibodies is available covering the first 100 days after vaccination. Methods: We reviewed all the publications regarding the immunologic consequences of BNT162b2 and mRNA-1273 vaccination. A summary of specific antibodies concentration and neutralizing antibodies titers elicited by each vaccine is provided. Results: BNT162b2 and mRNA-1273 displayed a reassuring safety and efficacy profile, with the latter above 94%. They can elicit specific antibodies titers and neutralizing antibodies concentrations that are far superior from those observed among COVID-19 human convalescent serum, across a wide span of age, for at least 100 days after vaccination. Moreover, the vaccine-induced T cellular response is oriented toward a T H 1 response and no evidence of vaccine-enhanced disease have been reported. Discussion: BNT162b2 and mRNA-1273 can elicit specific antibodies titers and neutralizing antibodies concentrations above those observed among COVID-19 human convalescent serum in the first 100 days after vaccination. Data about vaccine efficacy in those with previous COVID-19 or immunocompromised is still limited.
【저자키워드】 COVID-19, antibodies, SARS-CoV-2, neutralization test, RNA vaccine, CTL, 【초록키워드】 neutralizing antibody, Efficacy, Vaccine, vaccination, mRNA-1273, BNT162b2, Immunocompromised, age, convalescent serum, disease, cellular response, Evidence, Concentration, mRNA-based vaccine, consequence, shown, reported, specific antibody, approved, provided, elicit, elicited, neutralizing antibodies titer, of BNT162b2, 【제목키워드】 review, mRNA, MINI, consequence, Result,