SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are present in the mucosa, more precisely in saliva, after a recovered infection and also following vaccination. We report here the antibody persistence in plasma and in saliva up to 15 months after mild COVID-19. The IgG antibody response was measured every two months in 72 participants using an established and validated in-house ELISA assay. In addition, the virus inhibitory activity of plasma antibodies was assessed in a surrogate virus neutralization test before and after vaccination. SARS-CoV-2-specific antibody concentrations remained stable in plasma and saliva and the response was strongly boosted after one dose COVID-19 vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, Saliva, vaccination, antibody, neutralization, convalescent, mucosa, 【초록키워드】 Infection, virus, IgG antibody, SARS-CoV-2 antibody, COVID-19 vaccination, persistence, virus neutralization test, Mild, plasma, dose, antibody concentration, in-house ELISA, plasma antibody, participant, inhibitory activity, Defense, was measured, addition, remained, 【제목키워드】 Month,