Abstract
Background: Laboratory testing is commonly performed in patients with COVID-19. Each of the laboratory parameters has potential value for risk stratification and prediction of COVID-19 outcomes. This systematic review and meta-analysis aimed to evaluate the difference between these parameters in severe and nonsevere disease and to provide the optimal cutoff value for predicting severe disease.
Method: We performed a systematic literature search through electronic databases. The variables of interest were serum procalcitonin, albumin, C-reactive protein (CRP), D-dimer, and lactate dehydrogenase (LDH) levels in each group of severity outcomes from COVID-19.
Results: There were a total of 4848 patients from 23 studies. Our meta-analysis suggest that patients with severe COVID-19 infections have higher procalcitonin, (mean difference 0.07; 95% CI 0.05-0.10; p < 0.00001), CRP (mean difference 36.88; 95% CI 29.10-44.65; p < 0.00001), D-Dimer (mean difference 0.43; 95% CI 0.31-0.56; p < 0.00001), and LDH (mean difference 102.79; 95% CI 79.10-126.49; p < 0.00001) but lower levels of albumin (mean difference -4.58; 95% CI -5.76 to -3.39; p < 0.00001) than those with nonsevere COVID-19 infections. The cutoff values for the parameters were 0.065 ng/mL for procalcitonin, 38.85 g/L for albumin, 33.55 mg/L for CRP, 0.635 μ/L for D-dimer, and 263.5 U/L for LDH, each with high sensitivity and specificity.
Conclusion: This meta-analysis suggests elevated procalcitonin, CRP, D-dimer, and LDH and decreased albumin can be used for predicting severe outcomes in COVID-19.
Keywords: Biomarker; COVID-19; Coronavirus; Laboratory; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Biomarker, Laboratory, 【초록키워드】 Meta-analysis, SARS-CoV-2, Biomarker, severity, LDH, systematic review, C-reactive protein, CRP, D-dimer, procalcitonin, outcome, lactate dehydrogenase, Laboratory testing, outcomes, risk stratification, serum, Sensitivity and specificity, Patient, albumin, Laboratory parameters, disease, Lactate, severe disease, Severe COVID-19 Infection, 95% CI, COVID-19 infections, dimer, mean difference, Each, systematic literature search, severe COVID-19 infections, e parameters, cutoff value, parameter, variable, laboratory parameter, performed, evaluate, elevated, can be used, patients with COVID-19, 【제목키워드】 systematic review, outcome, predictor, marker, hematologic,