Abstract
Several studies have found an association of COVID-19 disease severity with Vitamin D deficiency and higher levels of anti-SARS-CoV-2 IgGs. The aim of this study was to determine whether levels of Vitamin D and “inflammatory state” influence the magnitude of anti-SARS-CoV-2 IgGs levels in COVID-19 patients. For this purpose, in 67 patients levels of anti-SARS-CoV-2 IgG were measured in week 4 whereas in 52 patients levels of Vitamin D were measured in week 1 after symptom onset. We found that low Vitamin D levels were significantly associated with age and disease severity whereas there was a trend without significance, towards negative correlation of Vitamin D with anti-SARS-CoV-2 IgG. Anti-SARS-CoV-2 IgG were significantly higher in older ages, patients with severe disease, diabetes and those who received corticosteroid and antibiotic therapy. There was a positive correlation of anti-SARS-CoV-2 IgG with IL-6, CRP, LDH, ESR and with percentages of granulocytes. In conclusion, Vitamin D and anti-SARS-CoV-2 IgG share common parameters associated with inflammatory state. However, even though Vitamin D protects against severe forms of COVID-19 it could not directly affect anti-SARS-CoV-2 IgG production.
【초록키워드】 Corticosteroid, COVID-19, IgG, Vitamin D, IL-6, disease severity, LDH, CRP, anti-SARS-CoV-2, vitamin D deficiency, anti-SARS-CoV-2 IgG, Patient, age, ESR, COVID-19 patients, association, severe disease, inflammatory state, symptom onset, Antibiotic therapy, Older, positive correlation, COVID-19 disease severity, vitamin D level, negative correlation, IgGs, parameter, Affect, PROTECT, significantly, form, determine, magnitude, significantly higher, were measured, diabete, percentage, 【제목키워드】 Vitamin D, Inflammatory marker, COVID-19 patient, relationship, anti-SARS-CoV-2 IgG antibody,