One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, mass spectrometry, targeted proteomics, PRM, parallel reaction monitoring, virus proteomics., targeted mass spectrometry, virus diagnostics, peptide selection,
【저자키워드】 COVID-19, SARS-CoV-2, mass spectrometry, targeted proteomics, PRM, parallel reaction monitoring, virus proteomics., targeted mass spectrometry, virus diagnostics, peptide selection,