Abstract
The outbreak of coronavirus disease (COVID-19) has brought great challenges to the world. The objectives of this study were to describe the baseline characteristics and changes of biomarkers of these COVID-19 patients and identify predictive value of the above markers for patient death. Using patient death as the observational endpoints, clinical data of inpatients in a special ward for COVID-19 in Wuhan, China were retrospectively collected. Univariate and multivariate Cox regression analyses were used to evaluate prognostic value of baseline characteristics and laboratory data changes. This study included clinical data of 75 patients. Age, c-reactive protein (CRP) and interleukin-6 levels were independent predictors of patient death. Survivors were characterized as having declining neutrophil counts, D-dimer, N-terminal pronatriuretic peptide, troponin I (TnI) and c-reactive protein levels, while counts of lymphocyte gradually came back. Non-survivors were characterized with increasing white blood cell counts (WBC) and neutrophil counts. Changes of WBC, TnI and interleukin-6 were also independently associated with patient death. Older age, baseline CRP and IL-6 levels may be used as meaningful predictors to identify patients with poor prognosis. Changes of biomarkers should be closely monitored in the management of patients with COVID-19, while constantly increasing levels of WBC, TnI and interleukin-6 in the disease course also predict patient death.
Keywords: C-reactive protein; COVID-19; Interleukin-6; Leukocyte count; Troponin I.
【저자키워드】 COVID-19, interleukin-6, C-reactive protein, Leukocyte count, Troponin I., 【초록키워드】 coronavirus disease, coronavirus, Biomarker, Biomarkers, IL-6, neutrophil, interleukin-6, peptide, C-reactive protein, CRP, D-dimer, troponin, Predictive value, Protein, lymphocyte, interleukin, White blood cell, outbreak, management, Wuhan, Patient, Older age, age, WBC, predictor, troponin I, change, patients, predict, marker, Analysis, endpoints, independent predictors, COVID-19 patient, IL-6 levels, blood cell, Predictive, C-reactive protein (CRP, leukocyte, Inpatients, changes, Inpatient, Non-survivors, Prognostic value, baseline characteristics, Clinical data, laboratory data, multivariate Cox regression, disease course, poor prognosis, neutrophil counts, protein levels, patient death, N-terminal, Wuhan, China, Course, identify, collected, evaluate, the disease, characterized, were used, baseline, declining, IL-6 level, independent predictor, patients with COVID-19, TnI, 【제목키워드】 Biomarker, Characteristics, change, predict, prognosis of patient, with COVID-19,