Abstract
Introduction: Severe acute respiratory syndrome coronavirus (SARS-CoV2) has imposed catastrophic impressions on the world. After all the focused researches conducted in the COVID-19 area, many features remain obscure. We have surveyed 1,363 outpatients with suspected COVID-19 in Tehran, Iran. The analysis emphasized on characteristics of patients with positive PCR or serology of SARS-CoV-2.
Methods: The nasopharyngeal swabs were tested for SARS-CoV2 PCR. Serum specimens were tested for SARS-CoV2 IgG and IgM. Clinical presentations of the patients, history of chronic diseases or drug use, contact with a possible COVID-19 patient and previous infection with SARS-COV2 were investigated.
Results: Of the total 1,363 investigated patients, 22% had positive SARS-CoV-2 PCRs, 82% had positive IgG, 38% had positive IgM, and 31% had both positive IgM and IgG values. Positive serologic tests were significantly associated with a positive PCR test obtained previously in the course of the current disease (P value<0.001). IgG and IgM antibody values were significantly associated with underlying disease, cough, fever, chills, fatigue, and myalgia (all P values <0.001). Dyspnea was significantly associated with IgG levels (P value = 0.01), yet it was not associated with IgM serology (P value = 0.2). Positive serology tests were not associated with symptoms of coryza. GI symptoms were not associated with positive IgG test (P value = 0.1), yet it did show an association with positive IgM test (P value = 0.02). Cough, fever, chills, myalgia fatigue, dyspnea, and GI symptoms were all significantly associated with positive PCR (all P values <0.001), and symptoms of coryza did not show a significant relationship (P value = 0.8).
Conclusion: Assessing antibody titers in outpatients is invaluable due to the epidemiological importance of investigations in mild or even asymptomatic cases. Since the number of such studies in non-hospitalized patients is not high, the current study can be used as a comparison model.
【초록키워드】 COVID-19, SARS-CoV-2, IgG, IgM, coronavirus, SARS-CoV2, fatigue, serology, antibody, Infection, Symptom, underlying disease, cough, chronic disease, Nasopharyngeal swab, Iran, PCR, Asymptomatic, clinical, Fever, Dyspnea, Patient, Antibody titer, Mild, serology test, epidemiological, disease, patients, association, Outpatient, Analysis, Contact, COVID-19 patient, myalgia, IgG and IgM, IgM and IgG, serologic test, p value, IgG test, acute respiratory syndrome, specimen, positive PCR test, IgM test, chills, positive, Tehran, positive PCR, PCRs, feature, catastrophic, Course, tested, significantly, investigated, conducted, can be used, Assessing, characteristics of patient, GI symptom, IgG level, 【제목키워드】 COVID-19, cross-sectional, serology test, role,