Abstract
Objective & aim: The coronavirus disease, so far (COVID-19) has brought about millions of infections and fatalities throughout the world. Our aim was to determine the correlation between rubella IGG titers with the severity COVID-19. MATERIALS & METHODS: This study was conducted among COVID-19 confirmed patients over 18 years of age. The disease severity levels were categorized by WHO interim guidance. The rubella-specific IgG antibody-titer spectrum was measured (within first 48 h of hospitalization) by enzyme-linked immunosorbent assay (ELISA).
Result: In a study of 46 inpatients with varying COVID-19 disease severity (mild, moderate, severe, and critical), we observed a negative correlation between rubella IgG antibody titers and COVID-19 severity (P-Value = 0.017), There was an interaction between COVID-19 vaccination history and rubella IGG on severity COVID-19 (P-Value = 0.0015). There was an interaction between age group under 44 years (including national measles- rubella (MR) vaccination in Iran) and rubella IGG titers on severity COVID-19 too (p-value = 0.014).
Conclusion: In conclusion, MR vaccination seems to have a positive effect in reducing the severity of the disease, emphasizing that, the important and separate effect of the IGG rubella (due to natural or extrinsic immunity) titers is determining.
Keywords: COVID-19; Immunoglobulin G; Rubella.
【저자키워드】 COVID-19, Immunoglobulin G, Rubella., 【초록키워드】 coronavirus disease, IgG, vaccination, Immunity, Hospitalization, severity, disease severity, Infection, COVID-19 severity, ELISA, Iran, COVID-19 vaccination, Mild, age, WHO, correlation, Critical, moderate, Guidance, fatality, Interaction, rubella, IgG antibody titer, Inpatient, COVID-19 disease severity, negative correlation, National, positive, objective, enzyme-linked immunosorbent, was measured, the disease, conducted, determine, reducing, extrinsic, COVID-19 confirmed patient, 【제목키워드】 severity, COVID, Immunoglobulin, rubella, Affect,