Abstract
Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong antibody responses achieve sterilizing immunity. Thus far, biomarkers associated with levels of vaccine-elicited antibody response are still lacking. Here, we studied the antibody response of age- and gender-controlled healthy cohort, who received inactivated SARS-CoV-2 vaccines and profiled the B cell receptor repertoires in longitudinally consecutive samples. Upon vaccination, all vaccinated individuals displayed a convergent antibody response with shared common antibody clones and public neutralizing antibodies. Strikingly, poor vaccine-responders are distinguishable from strong vaccine-responders by a biased V-usage before vaccination and IgG to IgM mRNA ratio. These findings reveal molecular signatures associated with the different levels of vaccine-induced antibody response, which could be further developed into biomarkers for the design of vaccination strategies.
Keywords: B cell receptor; COVID-19; SARS-CoV-2; antibody response; class switch recombination; inactivated vaccine.
【저자키워드】 COVID-19, SARS-CoV-2, Antibody Response, inactivated vaccine., B cell receptor, class switch recombination, 【초록키워드】 IgG, IgM, vaccination, Biomarker, Immunity, Neutralizing antibodies, antibody, Infection, SARS-CoV-2 vaccine, B cell, Reinfection, Cohort, Inactivated vaccine, mRNA, Vaccination strategies, age, receptor, molecular, inactivated, recipient, vaccinated individual, clone, vaccine-induced antibody response, healthy, individuals, the antibody response, 【제목키워드】 SARS-CoV-2 vaccine, B cell, response, receptor,