Abstract
This case series describes 9 patients diagnosed with myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorder (MOGAD) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients developed neurological symptoms between 4 days and 5 weeks following SARS-CoV-2 infection. Myelitis was observed in 4 patients; 4 presented with optic neuritis; and encephalopathy was observed in 3. Serum MOG-IgG cell-based assay was medium or high positive in each case. The majority of patients had near-complete recovery following acute immunosuppression. This series adds to the growing number of cases of central nervous system demyelination following SARS-CoV-2 infection and highlights a potential role of infection in the immunopathogenesis of MOGAD.
Keywords: COVID-19; MOGAD; Optic neuritis; SARS-CoV-2; Transverse myelitis.
【저자키워드】 COVID-19, SARS-CoV-2, Transverse myelitis., Optic neuritis, MOGAD, 【초록키워드】 coronavirus, SARS-COV-2 infection, Infection, Immunosuppression, Immunopathogenesis, Patient, Encephalopathy, glycoprotein, Central nervous system, Myelitis, Demyelination, transverse myelitis, acute respiratory syndrome, medium, disorder, positive, Neurological symptom, highlight, diagnosed, case sery, majority, Optic, 【제목키워드】 disorder, case sery, Myelin,