Abstract
Introduction: A new treatment for coronavirus disease (COVID-19), REGN-COV2, a cocktail consisting of two neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been approved for patients at a risk of developing more severe disease.
Methods: We retrospectively reviewed patients recently diagnosed with COVID-19 with risk factors for severe infection, who were treated with the REGN-COV2 antibody cocktail between July and September 2021. The REGN-COV2 antibody cocktail was administered to patients within 7 days of disease onset, with an oxygen saturation of >93%, and with at least one comorbidity. We investigated the percentage of patients with COVID-19-related hospitalization or death, the duration of symptoms after treatment, and the adverse effects of treatment.
Results: A total of 108 patients were reviewed. Of them, 64% were aged ≥50 years, 31% had obesity, 36% had hypertension, and 18% had diabetes. In addition, 49% had multiple risk factors for severe COVID-19. Overall, 12 patients (11%) needed COVID-19-related hospitalization. No adverse effects of treatment were observed.
Conclusions: This study shows that treatment with the REGN-COV2 antibody cocktail is safe and beneficial in patients at a risk of developing severe COVID-19.
Keywords: Casirivimab; Imdevimab; Neutralizing monoclonal antibodies; SARS-CoV-2.
【저자키워드】 SARS-CoV-2, Casirivimab, Imdevimab, neutralizing monoclonal antibodies, 【초록키워드】 COVID-19, Treatment, coronavirus disease, neutralizing antibody, SARS-CoV-2, Severe infection, coronavirus, severe COVID-19, Hospitalization, obesity, Comorbidity, risk, diabetes, risk factor, hypertension, oxygen saturation, antibody cocktail, Patient, death, REGN-CoV2, monoclonal, severe disease, disease onset, Safe, adverse effect, acute respiratory syndrome, Administered, addition, investigated, approved, treated, diagnosed with COVID-19, duration of symptom, 【제목키워드】 observational study, antibody cocktail, Patient, Japan, REGN-CoV2,