Abstract
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
Keywords: ADCC; COVID-19; NK cell; mRNA vaccine.
【저자키워드】 COVID-19, mRNA vaccine, NK cell, ADCC, 【초록키워드】 coronavirus disease, SARS-CoV-2, coronavirus, vaccination, antibody, mRNA vaccine, Patient, recovered patients, natural infection, antibody-dependent cellular cytotoxicity, Concentration, natural killer, acute respiratory syndrome, plasma antibody, vaccinated individuals, Spike-specific antibody, Affect, plasma sample, significantly, induce, individuals, elicited, 【제목키워드】 SARS-CoV-2, potent, natural, Against,