Abstract
Background: Severe pneumonia is pathological manifestation of Coronavirus Disease 2019 (COVID-19), however complications have been reported in COVID-19 patients with a worst prognosis. Aim of this study was to evaluate the role of high sensitivity cardiac troponin I (hs-TnI) in patients with SARS-CoV-2 infection.
Methods: we retrospectively analysed hs-TnI values measured in 523 patients (median age 64 years, 68% men) admitted to a university hospital in Milan, Italy, and diagnosed COVID-19.
Results: A significant difference in hs-TnI concentrations was found between deceased patients (98 patients) vs discharged (425 patients) [36.05 ng/L IQR 16.5-94.9 vs 6.3 ng/L IQR 2.6-13.9, p < 0.001 respectively]. Hs-TnI measurements were independent predictors of mortality at multivariate analysis adjusted for confounding parameters such as age (HR 1.004 for each 10 point of troponin, 95% CI 1.002-1.006, p < 0.001). The survival rate, after one week, in patients with hs-TnI values under 6 ng/L was 97.94%, between 6 ng/L and the normal value was 90.87%, between the normal value and 40 ng/L was 86.98, and 59.27% over 40 ng/L.
Conclusion: Increase of hs-TnI associated with elevated mortality in patients with COVID-19. Troponin shows to be a useful biomarker of disease progression and worse prognosis in COVID-19 patients.
Keywords: COVID-19; cardiac troponin; hospitalization; mortality; serially measurements of hs-TnI.
【저자키워드】 COVID-19, Mortality, Hospitalization, cardiac troponin, serially measurements of hs-TnI., 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Biomarker, Prognosis, Pneumonia, SARS-COV-2 infection, Infection, troponin, Italy, cardiac troponin, Disease progression, sensitivity, Patient, Complication, age, survival rate, severe pneumonia, troponin I, patients, COVID-19 patients, Multivariate analysis, Concentration, Analysis, Deceased, independent predictors, COVID-19 patient, normal value, significant difference, 95% CI, median age, university hospital, worse prognosis, hs-TNI, parameter, men, evaluate, reported, diagnosed, elevated, analysed, adjusted, increase, discharged, independent predictor, IQR, patients with COVID-19, patients with SARS-CoV-2, 【제목키워드】 troponin I, patients with COVID-19,