Abstract
The coordinated efforts to stop the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) include massive immunization of the population at a global scale. The humoral immunity against COVID-19 is conferred by neutralizing antibodies (NAbs) that occur during the post-infection period and upon vaccination. Here, we provide robust data showing that potent neutralizing antibodies are induced in convalescent patients of SARS-CoV-2 infection who have been immunized with different types of vaccines, and patients with no previous history of COVID-19 immunized with a mixed vaccination schedule regardless of the previous infection. More importantly, we showed that a heterologous prime-boost in individuals with Ad5-nCoV (Cansino) vaccine induces higher NAbs levels in comparison to a single vaccination scheme alone.
【초록키워드】 COVID-19, neutralizing antibody, Vaccine, coronavirus, SARS-CoV2, vaccination, Vaccines, SARS-COV-2 infection, Infection, immunization, Spread, Humoral immunity, Patient, convalescent patient, NAb, heterologous prime-boost, Post-infection, acute respiratory syndrome, individual, NAbs, effort, single vaccination, vaccination schedule, immunized, robust, include, occur, induce, 【제목키워드】 vaccination, Immunity, antibody, Heterologous, individual,