Abstract
Aim: To determine the efficacy and safety of inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with breast cancer.
Methods: In this multi- institutional cohort study, a total of 160 breast cancer patients (mean age of 50.01 ± 11.5 years old) were assessed for the SARS-CoV-2 Anti-Spike IgG and SARS-CoV2 Anti RBD IgG by ELISA after two doses of 0.5 mL inactivated, COVID-19 vaccine (BBIBP-CorV). All patients were followed up for three months for clinical COVID-19 infection based on either PCR results or imaging findings. Common Terminology Criteria for Adverse Events were used to assess the side effects.
Results: The presence of SARS-CoV-2 anti-spike IgG, SARS-CoV2 anti-RBD IgG, or either of these antibodies was 85.7%, 87.4%, and 93.3%. The prevalence of COVID-19 infection after vaccination was 0.7%, 0% and 0% for the first, second and third months of the follow-up period. The most common local and systemic side-effects were injection site pain and fever which were presented in 22.3% and 24.3% of patients, respectively.
Discussion: The inactivated SARS-CoV-2 vaccine (BBIBP-CorV) is a tolerable and effective method to prevent COVID-19.
Keywords: COVID-19 vaccine; Iran; SARS-CoV2; breast cancer; cancer; inactivated SARS-CoV-2 vaccine; malignancy; seroconversion.
【저자키워드】 Breast cancer, SARS-CoV2, COVID-19 vaccine, Cancer, Iran, Seroconversion, Inactivated SARS-CoV-2 vaccine, malignancy, 【초록키워드】 COVID-19, SARS-CoV-2, IgG, vaccination, antibody, Infection, Local, ELISA, SARS-CoV-2 vaccine, cohort study, Seroconversion, PCR, COVID-19 infection, Fever, Patient, age, Efficacy and safety, Side effects, patients, inactivated, BBIBP-CorV, dose, Anti-RBD IgG, Adverse, follow-up period, RBD IgG, Common Terminology Criteria, multi, Prevent, effective, breast cancer patient, injection site pain, SARS-CoV-2 anti-spike IgG, were used, determine, prevalence of COVID-19, systemic side-effect, the SARS-CoV-2, tolerable, were assessed, 【제목키워드】 SARS-CoV-2, immunogenicity, Safety, Breast, BBIBP-CorV, Trastuzumab,