Abstract
To investigate the dynamic changes of Krebs von den Lungen-6 (KL-6) among patients with coronavirus disease 2019 (COVID-19) and the role of KL-6 as a noninvasive biomarker for predicting long-term lung injury, the clinical information and laboratory tests of 166 COVID-19 patients were collected, and a correlation analysis between KL-6 and other parameters was conducted. There were 17 (10.2%, 17/166) severe/critical and 149 (89.8%, 149/166) mild COVID-19 patients in our cohort. Serum KL-6 was significantly higher in severe/critical COVID-19 patients than in mild patients (median 898.0 vs. 451.2 U/ml, p < .001). KL-6 was next confirmed to be a sensitive and specific biomarker for distinguishing mild and severe/critical patients and correlate to computed tomography lung lesions areas. Serum KL-6 concentration during the follow-up period (>100 days postonset) was well correlated to those concentrations within 10 days postonset (Pearson r = .867, p < .001), indicating the prognostic value of KL-6 levels in predicting lung injury after discharge. Finally, elevated KL-6 was found to be significantly correlated to coagulation disorders, and T cells subsets dysfunctions. In summary, serum KL-6 is a biomarker for assessing COVID-19 severity and predicting the prognosis of lung injury of discharged patients.
Keywords: COVID-19; KL-6; lung injury; prognosis.
【저자키워드】 COVID-19, Prognosis, KL-6, Lung injury, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Biomarker, Prognosis, T cells, COVID-19 severity, lung, Laboratory tests, Lung injury, discharged patients, discharge, Computed tomography, serum, Cohort, T cell, Patient, Mild, change, mild patients, Concentration, COVID-19 patient, noninvasive, Laboratory test, lung lesion, lung lesions, coagulation disorders, Prognostic value, Correlation analysis, follow-up period, clinical information, Pearson R, U/mL, Pearson, parameter, collected, significantly, elevated, conducted, median, correlated, significantly higher, subset, mild COVID-19 patient, mild patient, 【제목키워드】 disease severity, Lung injury, Retrospective analysis,