Abstract
It is unknown how long the immunity following COVID-19 vaccination lasts. The current systematic review provides a perspective on the persistence of various antibodies for available vaccines.Both the BNT162b2 and the mRNA-1273 induce the production of IgA antibodies, reflecting the possible prevention of the asymptomatic spread. The mRNA-1273 vaccine’s antibodies were detectable until 6 months, followed by the AZD1222, 3 months, the Ad26.COV2.S and the BNT162b2 vaccines within 2 months.The BNT162b2 produced anti-spike IgGs 11 days after the first dose and peaked at day 21, whereas the AZD1222 induced a neutralizing effect 22 days after the first dose.These vaccines induce T-cell mediated immune responses too. Each one of the AZD1222, Ad26.COV2.S, mRNA-1273 mediates T-cell response immunity at days 14-22, 15, and 43 after the first dose, respectively. Whereas for the BNT162b1 and BNT162b2 vaccines, T-cell immunity is induced 7 days and 12 weeks after the booster dose, respectively.
Keywords: Antibody persistence; COVID-19; Cell-mediated immunity; Humoral immunity; Immunogenicity; Long-term immunity; Long-term protection; SARS-CoV-2; Vaccines.
【저자키워드】 COVID-19, SARS-CoV-2, immunogenicity, Vaccines., Humoral immunity, antibody persistence, long-term immunity, Cell-mediated immunity, Long-term protection, 【초록키워드】 Vaccine, BNT162b2 vaccine, immune response, Immunity, antibody, mRNA-1273, T-cell Response, systematic review, BNT162b1, BNT162b2, Spread, Ad26.COV2.S, AZD1222, Asymptomatic, COVID-19 vaccination, anti-Spike IgG, persistence, T-cell, booster dose, T-cell immunity, mRNA-1273 vaccine, first dose, Perspective, IgA antibodies, BNT162b2 vaccines, neutralizing effect, produced, peaked, detectable, provide, induce, 【제목키워드】 Vaccine, Immunity, Longevity, approved,