Abstract
Coronavirus disease 2019 (COVID-19), the highly contagious illness caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the globe, becoming one of the most challenging public health crisis of our times. SARS-CoV-2 can cause severe disease associated with multiple organ damage. Cancer patients have a higher risk of SARS-CoV-2 infection and death. While the virus uses angiotensin-converting enzyme 2 (ACE2) as the primary entry receptor, the recent experimental and clinical findings suggest that some tumor markers, including CD147 (basigin), can provide an additional entry for SARS-CoV-2 infection through binding to the viral spike (S) protein. In the absence of specific viral drugs, blocking of CD147 might be a way to prevent virus invasion. Identifying other target proteins is of high importance as targeting the alternative receptors for SARS-CoV-2 might open up a promising avenue for the treatment of COVID-19 patients, including those who have cancer.
Keywords: Basigin; CD147; COVID-19; Emmprin; SARS-CoV-2; spike protein.
【저자키워드】 COVID-19, SARS-CoV-2, Spike protein, Basigin, CD147, Emmprin, 【초록키워드】 Treatment, coronavirus disease, Tumor, Coronavirus disease 2019, ACE2, coronavirus, SARS-COV-2 infection, Cancer, drugs, public health crisis, virus, angiotensin-converting enzyme 2, Spike protein, Health crisis, Basigin, CD147, Spread, Protein, Viral, Clinical findings, Patient, Cancer patients, death, receptor, respiratory, COVID-19 patients, binding, Angiotensin-converting enzyme, tumor markers, angiotensin, severe disease, Multiple organ damage, Invasion, open, Clinical finding, acute respiratory syndrome, higher risk, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, entry receptor, organ damage, viral spike, our times, target protein, contagious, while, identifying, Prevent, caused, globe, absence, 【제목키워드】 marker,