Abstract
Acute and chronic kidney failure is common in hospitalized patients with COVID-19, yet the mechanism of injury and predisposing factors remain poorly understood. We investigated the role of complement activation by determining the levels of deposited complement components (C1q, C3, FH, C5b-9) and immunoglobulin along with the expression levels of the injury-associated molecules spleen tyrosine kinase (Syk), mucin-1 (MUC1) and calcium/calmodulin-dependent protein kinase IV (CaMK4) in the kidney tissues of people who succumbed to COVID-19. We report increased deposition of C1q, C3, C5b-9, total immunoglobulin, and high expression levels of Syk, MUC1 and CaMK4 in the kidneys of COVID-19 patients. Our study provides strong rationale for the expansion of trials involving the use of inhibitors of these molecules, in particular C1q, C3, Syk, MUC1 and CaMK4 to treat patients with COVID-19.
Keywords: COVID-19; CaMK4; Complement activation; Immune complexes; Kidney injury; MUC1; SARS-CoV-2; Syk.
【저자키워드】 COVID-19, SARS-CoV-2, CaMK4, Complement activation, Immune complexes, Kidney injury, MUC1, Syk., 【초록키워드】 Trial, complement, hospitalized patients, inhibitors, CaMK4, Complement activation, Immune complexes, Kidney injury, MUC1, kidney, Protein, Immunoglobulin, expansion, mucin, inhibitor, calcium, mechanism, spleen, COVID-19 patients, chronic kidney failure, Injury, Kidney failure, protein kinase, tyrosine, predisposing factors, complement components, Activation, Factor, mechanism of injury, expression level, kidneys, treat, expression levels, component, Acute and chronic kidney failure, C5b-9, high expression levels, kidney tissues, kidney tissue, investigated, provide, hospitalized patient, C1q, high expression level, patients with COVID-19, with COVID-19, 【제목키워드】 Complement activation, kidney, increased expression, patients with COVID-19,