Abstract
Despite the burgeoning field of coronavirus disease-19 (COVID-19) research, the persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralising antibodies remains unclear. This study validated two high-throughput immunological methods for use as surrogate live virus neutralisation assays and employed them to examine the half-life of SARS-CoV-2 neutralising antibodies in convalescent plasma donations made by 42 repeat donors between April and September 2020. SARS-CoV-2 neutralising antibody titres decreased over time but typically remained above the methods’ diagnostic cut-offs. Using this longitudinal data, the average half-life of SARS-CoV-2 neutralising antibodies was determined to be 20.4 days. SARS-CoV-2 neutralising antibody titres appear to persist in the majority of donors for several months. Whether these titres confer protection against re-infection requires further study and is of particular relevance as COVID-19 vaccines become widely available.
Keywords: COVID-19; Convalescent donor; Half-life; Neutralising antibodies; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Neutralising Antibodies, half-life, Convalescent donor, 【초록키워드】 convalescent plasma, SARS-CoV-2, coronavirus, COVID-19 vaccine, diagnostic, Coronavirus disease-19, persistence, neutralising antibody, Research, Re-infection, neutralisation assay, Live virus, Donor, Longitudinal data, acute respiratory syndrome, average, titre, cut-offs, neutralising antibody titre, immunological, remained, was determined, majority, SARS-CoV-2 neutralising antibody, 【제목키워드】 anti-SARS-CoV-2 antibody, neutralising, COVID-19 convalescent donor, Determination,