Abstract
A low count of CD4 + and CD8 + lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4 + T and CD8 + T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4 + cells correlated with lower CD4 + counts. A higher expression of CD95 in CD4 + and CD8 + lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
Keywords: CD95 (Fas); COVID-19; PD-1; apoptosis; exhaustion.
【저자키워드】 COVID-19, Apoptosis, PD-1, CD95 (Fas), Exhaustion, 【초록키워드】 coronavirus disease, Apoptosis, Coronavirus disease 2019, Lymphocytes, T cells, CD4, CD8, flow cytometry, Laboratory, PD-1, lymphocyte, T cell, COVID-19 infection, Exhaustion, molecules, expression, laboratory finding, COVID-19 patient, shift, hallmark, activated T cells, controls, Cell, FAS, events, correlated, significantly higher, expressing, 【제목키워드】 Lymphocytes, PD-1, Peripheral blood, expression, COVID-19 patient, T lymphocyte, FAS, Increased,