Abstract
After the outbreak of COVID-19, billions of vaccines with different types have been administrated, including recombinant protein vaccines and mRNA vaccines. Although both types of SARS-CoV-2 vaccine can protect people from viral infection, their differences in humoral and cellular immune responses are still not clearly understood. In this study, we made a head-to-head comparison between an mRNA vaccine candidate and a recombinant protein vaccine we developed previously. Results demonstrated that both vaccine candidates could elicit high specific binding and neutralizing antibody titers in BALB/c mice, but with bias towards different IgG subtypes. Besides, the mRNA vaccine candidate induces higher cellular immune responses than the recombinant protein vaccine. To date, this is the first reported study to directly compare the immune responses of both arms between SARS-CoV-2 mRNA and recombinant vaccines.
Keywords: IgG subclass antibodies; SARS-CoV-2; cellular immune response; mRNA vaccine; protein vaccine.
【저자키워드】 SARS-CoV-2, mRNA vaccine, Cellular immune response, protein vaccine, IgG subclass antibodies, 【초록키워드】 COVID-19, IgG, viral infection, Vaccine, immune response, recombinant protein vaccine, immune, SARS-CoV-2 vaccine, mRNA vaccines, Protein, outbreak, mRNA, vaccine candidate, Head-to-head comparison, Neutralizing antibody titer, binding, cellular, humoral, recombinant vaccines, Subtypes, BALB/c mice, Arm, PROTECT, Result, reported, demonstrated, elicit, induce, 【제목키워드】 mRNA, response, recombinant, candidate,