Abstract
Aim: This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.
Methods: For 118 diabetic patients, laboratory measurements and clinical outcomes were compared between males and females. This study also compared inflammatory ratios obtained from combinations of six inflammatory markers between the two groups. The risk factors for mortality were identified through logistic regression.
Results: Males were 54 (45.8%) and females were 64 (54.2%). Males showed a significant increase in ALT (P = 0.003), CRP (P = 0.03), mean platelet volume (MPV)-to-lymphocyte ratio (P = 0.001), and C-reactive protein-to-albumin ratio (P = 0.044), whereas females had a significant increase in lymphocytes (P < 0.005) and MPV (P = 0.01). In all participants, multivariate analysis illustrated that older age, male sex, increased serum total bilirubin, and decreased PO 2 were significant independent predictors of mortality (P < 0.05).
Conclusion: In severe COVID-19 patients with diabetes, there were significant sex differences in many laboratory characteristics with a higher risk of mortality among males.
Keywords: COVID-19; Diabetes; Laboratory; Pneumonia; Sex.
【저자키워드】 COVID-19, Pneumonia, diabetes, Laboratory, Sex., 【초록키워드】 Risk factors, Lymphocytes, Mortality, inflammatory markers, CRP, diabetes, risk factor, clinical outcomes, Clinical outcome, lymphocyte, serum, male, female, Interpretation, albumin, Older age, Platelet, Laboratory parameters, Logistic regression, laboratory characteristics, Inflammatory marker, Sex difference, Multivariate analysis, ALT, Evidence, Combination, diabetic patients, Analysis, Inflammatory, Male sex, Bilirubin, mean platelet volume, Volume, Diabetic, Participants, two groups, higher risk, total bilirubin, All participants, significant increase, combinations, severe COVID-19 patients, laboratory measurements, females, laboratory parameter, males, MPV, independent predictor, laboratory measurement, severe COVID-19 patient, 【제목키워드】 retrospective cohort study, discrepancy, laboratory parameter, severe COVID-19 patient,