Abstract
Background: This study aimed to investigate the seroreactivity of Coronavirus disease 2019 (COVID-19) vaccination and its adverse events among systemic lupus erythematosus (SLE) patients, rheumatoid arthritis (RA) patients, and healthy controls (HCs).
Methods: A total of 60 SLE patients, 70 RA patients and 35 HCs, who received a complete inactivated COVID-19 vaccine (Vero cells) regimen, were recruited in the current study. Serum IgG and IgM antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were determined by using chemiluminescent microparticle immunoassay (CMIA).
Results: There were no significant differences regarding the seroprevalences of IgG and IgM antibodies against SARS-CoV-2, and the self-reported vaccination-related adverse events among SLE patients, RA patients and HCs. The inactivated COVID-19 vaccines appeared to be well-tolerated and moderately immunogenic. In addition, case-only analysis indicated that in SLE patients, the disease manifestation of rash and anti-SSA autoantibody were associated with seroprevalence of IgG antibody against SARS-CoV-2, whereas the uses of ciclosporin and leflunomide had influence on the seroprevalence of IgM antibody against SARS-CoV-2. In RA patients, rheumatoid factor (RF) appeared to be associated with the seroprevalence of IgG antibody against SARS-CoV-2.
Conclusion: Our study reveals that the seroprevalences of IgG and IgM antibodies against SARS-CoV-2 and vaccination-related adverse effects are similar among SLE, RA and HCs, suggesting that COVID-19 vaccine is safe and effective for SLE and RA patients to prevent from the pandemic of COVID-19.
Keywords: COVID-19; RA; SARS-CoV-2; SLE; Vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, vaccination, RA, SLE, 【초록키워드】 Coronavirus disease 2019, COVID-19 vaccine, vaccination, antibody, systemic lupus erythematosus, coronavirus 2, rheumatoid arthritis, immunoassay, IgG antibody, CMIA, adverse event, Patient, respiratory, patients, Rash, inactivated, leflunomide, Analysis, Safe, autoantibody, IgG and IgM, regimen, adverse effect, no significant difference, healthy control, IgM antibody, Vero cells, immunogenic, SLE patients, pandemic of COVID-19, Microparticle, Complete, Prevent, effective, recruited, indicated, addition, the disease, reveal, HCs, 【제목키워드】 Seroprevalence, systemic lupus erythematosus, rheumatoid arthritis, adverse event, SARS-CoV-2-specific antibody,