Abstract
Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-19, is essential to help control the infection. The neutralization activity of plasma from patients with COVID-19 decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we select plasma from a cohort of convalescent patients with COVID-19 and selectively deplete immunoglobulin A, M, or G before testing the remaining neutralizing capacity of the depleted plasma. We find that depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of immunoglobulin M (IgM).
Keywords: COVID-19; IgA; IgG; IgM; SARS-CoV-2; convalescent plasma; neutralization; spike glycoprotein.
【저자키워드】 COVID-19, convalescent plasma, SARS-CoV-2, IgG, IgM, neutralization, spike glycoprotein, IgA, 【초록키워드】 therapy, susceptibility, spike glycoprotein, Infection, Cohort, Immunoglobulin, Patient, Virus neutralization, plasma, neutralizing capacity, Autoimmune, convalescent, immunoglobulin A, convalescent patient, humoral, observation, characterization, help, neutralization activity, etiological agent, decrease, receiving, explain, deplete, impair, patients with COVID-19, with COVID-19, 【제목키워드】 Neutralizing activity, Major,