Abstract
Background: Krebs von den Lungen-6 (KL-6) is a molecule that is predominantly expressed by damaged alveolar type II cells, and has been proposed as a marker of COVID-19 and the severity of the disease. Here, we performed a meta-analysis to determine whether KL-6 could be used as a prognostic factor for severe COVID-19.
Methods: PubMed, Cochrane and Google Scholar were searched until April 20, 2021, and 7 studies were included. KL-6 was considered as the outcome and pooled in meta-analyses.
Results: All included studies compared KL-6 in severe and non-severe patients. Serum KL-6 was higher in severe COVID-19 patients compared to non-severe (n = 6; SMD = 1.25; 95% CI: 0.99-1.5; P < 0.001) and healthy controls (n = 4; SMD = 3.07; 95% CI: 1.36-4.8; P < 0.001).
Conclusion: This data collection revealed the potential clinical significance of KL-6 as a non-expensive predictive biomarker in severe COVID-19 and for the categorization of COVID-19 clinical severity.
Keywords: COVID-19; KL-6; Mucin-1.
【저자키워드】 COVID-19, KL-6, Mucin-1., 【초록키워드】 Meta-analysis, Biomarker, severe COVID-19, severity, outcome, serum, cells, Clinical significance, marker, Clinical severity, Data collection, meta-analyses, Prognostic factor, Predictive, Google Scholar, healthy control, severe COVID-19 patients, non-severe patients, severe and non-severe patients, molecule, categorization, Alveolar Type II, SMD, performed, the disease, searched, determine, expressed, damaged, severe COVID-19 patient, 【제목키워드】 Meta-analysis, systematic review,