Dysregulated innate and adaptive immunity is a sign of SARS-CoV-2-induced disease and cancer. CD8^{+} T cells are important cells of the immune system. The cells belong to the adaptive immunity and take a front-line defense against viral infections and cancer. Extreme CD8^{+} T-cell activities in the lung of patients with a SARS-CoV-2-induced disease and within the tumor microenvironment (TME) will change their functionality into exhausted state and undergo apoptosis. Such diminished immunity will put cancer cases at a high-risk group for SARS-CoV-2-induced disease, rendering viral sepsis and a more severe condition which will finally cause a higher rate of mortality. Recovering responses from CD8^{+} T cells is a purpose of vaccination against SARS-CoV-2. The aim of this review is to discuss the CD8^{+} T cellular state in SARS-CoV-2-induced disease and in cancer and to present some strategies for recovering the functionality of these critical cells.
【저자키워드】 SARS-CoV-2, hypoxia, Cancer, Exhaustion, memory T cell, CD8+ T cell, immune checkpoint inhibitor (ICI), programmed death 1 receptor (PD-1).,