Abstract
Background: Immunizations against SARS-CoV-2 virus are now available and recommended, but the effect of additional dosing of the vaccine in immunocompromised MS patients is unknown.
Methods: Part I – A retrospective chart review of MS patients who were vaccinated against SARS-CoV-2 and tested commercially for Sars Covid Spike Protein Antibody between March 1 – June 30, 2021. Part II – Patients on treatment with anti-CD20 infusion medications who received a SARS-CoV-2 third mRNA vaccination dose August 13, 2021 – October 31, 2021 and were subsequently commercially tested for Sars Covid Spike Protein Antibody.
Results: Part I – A total of N = 208 MS patients, age range 23-76 were tested, with 49% (102/208) demonstrating a humoral response. Stratified by DMT type, patients treated with interferon, teriflunomide, or a remote history of alemtuzumab (>2 years since last DMT) yielded 100% measurable antibodies; >90% amongst patients treated with natalizumab, fumarates and glatiramer acetate; <50% measurable antibodies following vaccination in S1P modulators and anti-CD20 treated patients. Subsequently, in Part II – N = 40 patients on anti-CD20 treatments (33 ocrelizumab, 7 rituximab) who received 3 mRNA vaccinations yielded 20% humoral response.
Conclusions: MS patients are able to mount a humoral vaccine response to SARS-CoV-2, irrespective of the vaccine type administered; patients treated with S1P modulators and anti-CD20 agents are least likely to mount such a response with a typical dosing schedule. Patients treated with ocrelizumab/rituximab show a similar modest humoral immune system benefit following three doses as with standard dosing.
Keywords: Covid-19; Disease modifying treatment; Immunization; MS; Vaccine.
【저자키워드】 COVID-19, Vaccine, immunization, MS, Disease modifying treatment, 【초록키워드】 SARS-CoV-2, mRNA vaccination, vaccination, spike, antibody, interferon, SARS-CoV-2 virus, immune system, vaccine response, Patient, Immunocompromised, age, medication, patients, anti-CD20, retrospective, dose, humoral, fumarate, anti-CD20 treatment, treated patients, benefit, tested, treated, the vaccine, Part, patients treated, treatment with anti-CD20, 【제목키워드】 therapy, multiple sclerosis, disease, SARS-CoV-2 vaccination, dosing schedule, patients treated,