Abstract
Aim: To investigate the serum circulating DPP4 activity in patients with COVID-19 disease. Materials & methods: Serum samples from 102 hospitalized COVID-19 patients and 43 post-COVID-19 plasma donors and 39 SARS-CoV-2 naive controls and their medical data were used. Circulating DPP4 activities according to different COVID-19 disease peak severity (WHO) groups at sampling and at peak were assessed. Results: A significant decrease (p < 0.0001) in serum DPP4 activity was found in study groups of higher disease severity. When the circulating DPP4 activity was assessed as a prognostic marker, the logistic regression (p = 0.0023) indicated that the enzyme activity is a predictor of mortality (median 9.5 days before death) with receiver operating characteristic area under the curves of 73.33% (p [area = 0.5] < 0.0001) as single predictor and 83.45% (p [area = 0.5] < 0.0001) in combination with age among hospitalized patients with COVID-19. Conclusion: Decreased circulating DPP4 activity is associated with severe COVID-19 disease and is a strong prognostic biomarker of mortality.
Keywords: COVID-19; DPP4; SARS-CoV-2; T2DM; circulating DPP4 activity; disease severity; mortality; prognostic biomarker.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, disease severity, DPP4, T2DM, circulating DPP4 activity, prognostic biomarker., 【초록키워드】 severity, disease severity, hospitalized patients, DPP4, COVID-19 disease, activity, serum, Control, death, Logistic regression, Prognostic marker, sampling, plasma, age, WHO, group, characteristic, disease, severe COVID-19 disease, prognostic biomarker, Donor, hospitalized COVID-19 patient, Combination, receiver operating characteristic, study group, serum samples, study groups, significant decrease, circulating, material, enzyme activity, serum sample, indicated, median, were used, hospitalized patient, Decreased, patients with COVID-19, were assessed, with COVID-19, 【제목키워드】 outcome, Dipeptidyl peptidase-4, prognostic, Inpatient, circulating, Decreased,