The 3C-like protease (M^{pro}, 3CL^{pro}) plays a key role in the replication process in coronaviruses (CoVs). The M^{pro} is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-CoV M^{pro} in vitro experiments. In this study, we resolved the SARS-CoV M^{pro} with baicalein by X-ray diffraction at 2.25 Å (PDB code 7XAX), which provided a structural basis for the research and development of baicalein as an anti-CoVs drug.
All Keywords
【저자키워드】 SARS-CoV, 3C-like protease, baicalein,
【저자키워드】 SARS-CoV, 3C-like protease, baicalein,