Abstract
Objectives: To better understand the factors that influence the humoral immune response to vaccination against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs).
Methods: Patients and controls from a large COVID-19 study, with (1) no previous history of COVID-19, (2) negative baseline anti-SARS-CoV-2 IgG test and (3) SARS-CoV-2 vaccination at least 10 days before serum collection were measured for anti-SARS-CoV-2 IgG. Demographic, disease-specific and vaccination-specific data were recorded.
Results: Vaccination responses from 84 patients with IMID and 182 controls were analysed. While all controls developed anti-SARS-CoV-2 IgG, five patients with IMID failed to develop a response (p=0.003). Moreover, 99.5% of controls but only 90.5% of patients with IMID developed neutralising antibody activity (p=0.0008). Overall responses were delayed and reduced in patients (mean (SD): 6.47 (3.14)) compared with controls (9.36 (1.85); p<0.001). Estimated marginal means (95% CI) adjusted for age, sex and time from first vaccination to sampling were 8.48 (8.12-8.85) for controls and 6.90 (6.45-7.35) for IMIDs. Significantly reduced vaccination responses pertained to untreated, conventionally and anticytokine treated patients with IMID.
Conclusions: Immune responses against the SARS-CoV-2 are delayed and reduced in patients with IMID. This effect is based on the disease itself rather than concomitant treatment.
Keywords: COVID-19; biological therapy; epidemiology; vaccination.
【저자키워드】 COVID-19, vaccination, Epidemiology, biological therapy, 【초록키워드】 SARS-CoV-2, vaccination, Sex, serum, anti-SARS-CoV-2 IgG, response, Patient, Control, age, humoral immune response, demographic, SARS-CoV-2 vaccination, Factor, 95% CI, first vaccination, while, Immune-mediated inflammatory disease, FIVE, develop, the disease, analysed, reduced, adjusted, responses against, were measured, were recorded, baseline, concomitant treatment, Estimated, marginal mean, neutralising antibody activity, the SARS-CoV-2, treated patient, vaccination response, 【제목키워드】 response, Patient, SARS-CoV-2 vaccination, Immune-mediated inflammatory disease, treated,