Abstract
Objectives: To compare the clinical profile, treatment, and outcomes of PCR-positive and PCR-negative antibody-positive critically ill children with multisystem inflammatory syndrome (MIS-C).
Methods: This retrospective observational study was done at a tertiary care coronavirus disease 19 (COVID-19) pediatric intensive care unit in India. The baseline characteristics, clinical profile, treatment, and outcomes in seventeen critically ill children diagnosed with MIS-C were analyzed from 1 July to 31 October, 2020.
Results: Sixteen out of 17 children presented with hypotensive shock and respiratory distress. Mean (SD) age of PCR-negative antibody-positive and PCR-positive children was 11 (4.4) and 5 (3.7) years, respectively (P=0.007). The former group had significantly higher mean (SD) D-dimer levels [16,651 (14859) ng/mL vs 3082 (2591) ng/mL; P=0.02]. All received intensive care management and steroid therapy; 7 children received intravenous immunoglobulin. 14 children survived and 3 died.
Conclusions: The outcome of children with MIS-C was good if recognized early and received intensive care.
【초록키워드】 COVID-19, Treatment, coronavirus disease, Intravenous immunoglobulin, intensive care, pediatric, children, India, outcome, MIS-C, Shock, Critically ill, management, age, Care, retrospective, D-dimer level, Inflammatory, distress, baseline characteristics, PCR-positive, syndrome, PCR-negative, analyzed, died, diagnosed, significantly higher, survived, was done, children with MIS-C, 【제목키워드】 SARS-CoV-2, clinical, Spectrum,