Abstract
We herein report a case of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 24-year-old woman developed unilateral optic neuritis 3 weeks after contracting coronavirus disease 2019 (COVID-19), followed by intracranial demyelinating lesions and myelitis. Since serum anti-MOG antibody was positive, we diagnosed MOG antibody-associated disease. Immunotherapy with steroids resulted in the rapid improvement of neurological symptoms. This is a suggestive case, as there are no reports of MOG antibody-associated disease with multiple neurological lesions occurring after COVID-19. The response to immunotherapy was favorable. This case suggests that it is important to measure anti-MOG antibodies in patients who develop inflammatory neurological disease after COVID-19.
Keywords: COVID-19; MOG antibody-associated disease; SARS-CoV-2; demyelinating autoimmune disease; myelitis; optic neuritis.
【저자키워드】 COVID-19, SARS-CoV-2, Myelitis, optic neuritis., MOG antibody-associated disease, demyelinating autoimmune disease, 【초록키워드】 coronavirus disease, coronavirus, antibody, Immunotherapy, Infection, serum, Patient, glycoprotein, Neurological symptoms, Autoimmune, disease, MOG, Inflammatory, neurological, steroid, lesion, Neurological disease, acute respiratory syndrome, positive, develop, diagnosed, 【제목키워드】 review, literature, Oligodendrocyte, report, Myelin,