Abstract
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first affected humans in China on December 31, 2019 (Shi et al., 2020). Coronaviruses generally cause mild, self-limiting upper respiratory tract infections in humans, such as the common cold, pneumonia, and gastroenteritis (To et al., 2013; Berry et al., 2015; Chan et al., 2015). According to the Report of the World Health Organization (WHO)-China Joint Mission on COVID-19 (WHO, 2020), the case fatality rate of COVID-19 increases with age, while the rate among males is higher than that among females (4.7% and 2.8%, respectively). Since an effective vaccine and specific anti-viral drugs are still under development, passive immunization using the convalescent plasma (CP) of recovered COVID-19 donors may offer a suitable therapeutic strategy for severely ill patients in the meantime. So far, several studies have shown therapeutic efficacy of CP transfusion in treating COVID-19 cases. A pilot study first reported that transfusion of CP with neutralizing antibody titers above 1:640 was well tolerated and could potentially improve clinical outcomes through neutralizing viremia in severe COVID-19 cases (Chen et al., 2020). Immunoglobulin G (IgG) and IgM are the most abundant and important antibodies in protecting the human body from viral attack (Arabi et al., 2015; Marano et al., 2016). Our study aimed to understand the aspects of plasma antibody titer levels in convalescent patients, as well as assessing the clinical characteristics of normal, severely ill, and critically ill patients, and thus provide a basis for guiding CP therapy. We also hoped to find indicators which could serve as a reference in predicting the progression of the disease.
Keywords: Coronavirus disease 2019 (COVID-19); Convalescent plasma; Clinical characteristics; Antibody titer.
【저자키워드】 convalescent plasma, Clinical characteristics, Coronavirus disease 2019 (COVID-19), antibody titer., 【초록키워드】 COVID-19, SARS-CoV-2, IgG, IgM, Coronavirus disease 2019, Vaccine, coronavirus, therapy, severe COVID-19, Pneumonia, antibody, Human, Infection, Infectious disease, progression, immunization, China, Convalescent patients, Immunoglobulin G, Viremia, humans, clinical, male, female, Mild, age, WHO, Neutralizing, common cold, upper respiratory tract, therapeutic strategy, critically ill patients, anti-viral drug, Neutralizing antibody titer, Donor, gastroenteritis, World Health Organization, acute respiratory syndrome, pilot study, plasma antibody, therapeutic efficacy, Fatality rate, treating COVID-19, report, offer, effective, shown, affected, caused, reported, the disease, increase, Berry, improve clinical outcome, severely ill patient, 【제목키워드】 China, Characteristics, clinical, plasma antibody, Zhejiang, patients with COVID-19,