Abstract
Background and Objectives: One of the most serious clinical outcomes in hospitalized patients with COVID-19 is severe acute respiratory syndrome (SARS). The aim is to analyze pharmacological treatment, survival and the main mortality predictors. Materials and Methods: A real-world data study from COVID-19-hospitalized patients with SARS from 1 March to 31 May 2020 has been carried out. Variables such as hospital length of stay, ventilation type and clinical outcomes have been taken into account. Results: In Castile and Leon, 14.03% of the 7307 in-hospital COVID-19 patients developed SARS, with a mortality rate of 42.53%. SARS prevalence was doubled in males compared to females, and 78.54% had an age of 65 years or more. The most commonly used medicines were antibiotics (89.27%), antimalarials (68.1%) and corticosteroids (55.9%). Survival of patients developing SARS was lower compared to patients without this complication (12 vs. 13 days). The main death predictors were disseminated intravascular coagulation (DIC) (OR: 13.87) and age (>65 years) (OR: 7.35). Conclusions: Patients older than 65 years who develop DIC have a higher probability of hospital death. Tocilizumab and steroids have been linked to a lower incidence of hospital death, being the main treatment for COVID-19 hospitalized patients with SARS.
Keywords: COVID-19; SARS-CoV-2; clinical findings; pharmacological treatment; severe acute respiratory syndrome; survival.
【저자키워드】 COVID-19, SARS-CoV-2, Severe acute respiratory syndrome, Clinical findings, Survival., pharmacological treatment, 【초록키워드】 Corticosteroid, Mortality, hospital, Ventilation, Antibiotics, predictors, real-world data, antimalarial, Clinical outcome, Medicine, Prevalence, Probability, survival, male, Patient, death, age, mortality rate, predictor, incidence, Disseminated intravascular coagulation, COVID-19 patient, steroid, In-hospital, acute respiratory syndrome, Older, material, variable, pharmacological, females, patients with SARS, develop, carried, hospitalized patient, treatment for COVID-19, with COVID-19, 【제목키워드】 clinical, respiratory, registry,