Abstract
Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the anti-spike IgG titers in 13,971 participants included in a French multicohort population-based serological survey on COVID-19 between April and October 2020 and followed-up with serological testing between May and October 2021. Eight follow-up profiles were defined depending on SARS-CoV-2 infection (0, 1 or 2) and COVID-19 vaccination (0, 1, 2 or 3). The anti-spike titer was lower in adults with no vaccination even in case of infection or reinfection, while it was higher in adults with infection followed by vaccination. The anti-spike titer was negatively correlated with age in vaccinated but uninfected adults, whereas it was positively correlated with age in unvaccinated but infected adults. In adults with 2 vaccine injections and no infection, the vaccine protocol, age, gender, and time since the last vaccine injection were independently associated with the anti-spike titer. The decrease in anti-spike titer was much more rapid in vaccinated than in infected subjects. These results highlight the strong heterogeneity of the antibody response against SARS-CoV-2 in the general population depending on previous infection and vaccination.
【초록키워드】 COVID-19, SARS-CoV-2, vaccination, protocol, SARS-COV-2 infection, Infection, Gender, heterogeneity, Adults, Reinfection, COVID-19 vaccination, Serological testing, anti-Spike IgG, age, Follow-up, General population, assessment, Critical, Anti-spike, determinant, intensity, profile, participant, French, serological survey, uninfected, decrease, highlight, defined, characterized, subjects, correlated, the vaccine, the antibody response, positively correlated, vaccine injection, 【제목키워드】 SARS-CoV-2, Infection, COVID-19 vaccination, General population, humoral,