Abstract
The situation of coronavirus disease 2019 (COVID-19) pandemic is rapidly evolving, and medical researchers around the globe are dedicated to finding cures for the disease. Drug repurposing, as an efficient way for drug development, has received a lot of attention. However, the huge amount of studies makes it challenging to keep up to date with the literature on COVID-19 therapeutic development. This review addresses this challenge by grouping the COVID-19 drug repurposing research into three large groups, including clinical trials, computational research, and in vitro protein-binding experiments. Particularly, to facilitate future drug discovery and the creation of effective drug combinations, drugs are organized by their mechanisms of action and reviewed by their efficacy measured by clinical trials. Providing this subtyping information, we hope this review would serve the scientists, clinicians, and the pharmaceutical industry who are looking at the new therapeutics for COVID-19 treatment.
Keywords: COVID-19; clinical trial; computational research; drug repurposing; in vitro protein interaction assay.
【저자키워드】 COVID-19, Drug repurposing, clinical trial, computational research, in vitro protein interaction assay., 【초록키워드】 Treatment, coronavirus disease, Drug repurposing, Coronavirus disease 2019, Efficacy, clinical trial, pandemic, Drug discovery, Drug development, clinical trials, pharmaceutical industry, drug, drug combinations, in vitro, COVID-19 treatment, Protein, therapeutic, Research, information, mechanism, Interaction, Clinicians, creation, situation, researcher, effective, globe, the disease, facilitate, groups, Providing, experiments, organized, 【제목키워드】 Protein, Interaction, screening methods,