Abstract
Objective: Health care workers (HCWs) are at increased risk for SARS-CoV-2 infection, however not all face the same risk. We aimed to determine IgG/IgM prevalence and risk factors associated with seropositivity in Chilean HCWs.
Study design and setting: This was a nationwide, cross-sectional study including a questionnaire and COVID-19 lateral flow IgG/IgM antibody testing. All HCWs in the Chilean public health care system were invited to participate following the country’s first wave.
Results: IgG/IgM positivity in 85,529 HCWs was 7.2%, ranging from 1.6% to 12.4% between regions. Additionally, 9.7% HCWs reported a positive PCR of which 47% were seropositive. Overall, 10,863 (12.7%) HCWs were PCR and/or IgG/IgM positive. Factors independently associated with increased odds ratios (ORs) for seropositivity were: working in a hospital, night shifts, contact with Covid-19, using public transport, male gender, age>45, BMI ≥30, and reporting ≥2 symptoms. Stress and/or mental health disorder and smoking were associated with decreased ORs. These factors remained significant when including PCR positive cases in the model.
Conclusions: HCWs in the hospital were at highest risk for COVID-19, and several independent risk factors for seropositivity and/or PCR positivity were identified.
Keywords: Antibody prevalence; Antibody testing; COVID-19; Health care workers; SARS-CoV-2; Vaccine priority.
【저자키워드】 COVID-19, SARS-CoV-2, Antibody testing, health care workers, Antibody prevalence, Vaccine priority., 【초록키워드】 public health, Health care, mental health, cross-sectional, SARS-COV-2 infection, hospital, Gender, risk, smoking, risk factor, Symptoms, Prevalence, lateral flow, PCR, HCWs, male, BMI, First wave, Care, questionnaire, seropositive, PCR positivity, Odds ratio, Contact, HCW, Transport, Factor, increased risk, PCR positive, independent risk factor, disorder, positive, positive PCR, regions, country, highest, reported, remained, determine, Chilean, 【제목키워드】 risk, Health, cross, Care, professional,