Abstract
Background: Vaccination is one of the most important tools to control the COVID-19 pandemic. However, there is little information on the antibody response in humans after the COVID-19 vaccination.
Methods: This single-center, prospective study was conducted in Yokohama, Japan. We included health care workers who had received two doses of COVID-19 vaccination (BNT162b2) 21 days apart. We measured serum immunoglobulin G (IgG) to nucleoprotein and spike protein of SARS-CoV-2 with commercially available kits before and 7, 14, and 35 days after the first dose of vaccination.
Results: A total of 104 workers participated in this study. Of these, 7 participants were seropositive with antibodies to spike protein at baseline and 4 of the 7 seropositive participants had COVID-19 history. The mean level of IgG to spike protein (QT) was 45.2, 1219, 2845, and 23489 AU/mL at baseline, on days 7, 14, and 35, respectively, although the values for nucleoprotein (NG) were 0.2, 0.21, 0.22, and 0.19 S/C, respectively. On day 7, QT in seropositive participants at baseline was elevated, whereas it was not elevated in seronegative participants at baseline until day 14.
Conclusions: QT was elevated over the cutoff in all the participants at day 35, but NG did not change between baseline and day 35.
Keywords: Antibody; COVID-19; Health care worker; Japan; Vaccination.
【저자키워드】 COVID-19, vaccination, antibody, Health care worker, Japan, 【초록키워드】 SARS-CoV-2, IgG, vaccination, Health care, COVID-19 pandemic, Prospective Study, Human, Spike protein, BNT162b2, serum, COVID-19 vaccination, Immunoglobulin, information, seropositive, dose, first dose, single-center, participant, Cutoff, elevated, conducted, the antibody response, baseline, participated, seronegative participant, seropositive participant, Yokohama, 【제목키워드】 COVID-19 vaccine, BNT162b2,