Abstract
Single-particle cryoelectron microscopy (cryo-EM), whose full capabilities have been realized only within the past decade, has had a pivotal role in the fight against COVID-19. This is due to the technique’s intrinsic power to depict both structural and dynamic features of molecules; in this case, of the spike protein of SARS-CoV-2. By now, numerous cryo-EM studies have furthered our understanding of spike protein-angiotensin-converting enzyme 2 (ACE2) receptor interactions, which has informed the design of effective vaccines, and have enabled the characterization of neutralizing antibody binding sites, which will lead to the design of novel therapeutics as the virus evolves.
Keywords: MERS-CoV; SARS-CoV-2; antibodies; molecular dynamics; receptor-binding domain; spike protein.
【저자키워드】 antibodies, SARS-CoV-2, molecular dynamics, MERS-CoV, spike protein., Receptor-binding domain, 【초록키워드】 COVID-19, neutralizing antibody, ACE2, virus, Spike protein, Microscopy, cryo-EM, receptor, molecular, interactions, binding, enzyme, Effective vaccines, feature, intrinsic, the spike protein, 【제목키워드】 COVID-19, Microscopy,