Abstract
Background: The hyperinflammatory state of multisystem inflammatory syndrome in children (MIS-C) predisposes to thromboembolic complications. We report a neonate with multiple cavitary lesions in lung, which we suspect could be a manifestation of multisystem inflammatory syndrome in neonate (MIS-N) following maternal COVID-19 infection during pregnancy.
Case report: Eight-day-old neonate was referred with fever and fast breathing. Mother was positive for COVID-19 in 29th week. COVID-19 reverse-transcription polymerase chain reaction was negative, however, antibodies were positive. He had increased leucocyte count, and elevated levels of C-reactive protein (CRP), procalcitonin, ferritin, lactate dehydrogenase, and d-dimer along with bilateral reticulonodular opacities on chest radiograph and multiple nodules with evidence of cavitation in both lungs on chest tomography. All cultures were negative. A possible diagnosis of MIS was made. Infant was treated with intravenous immunoglobulin (IVIG) which he responded to with resolution of symptoms.
Conclusion: Neonates exposed to COVID-19 should be evaluated for thromboembolic complications and IVIG can be one of the treatment modalities.
Keywords: COVID-19; multisystem inflammatory syndrome; neonate; pulmonary cavities; thromboembolism.
【저자키워드】 COVID-19, Multisystem inflammatory syndrome, Neonate, thromboembolism., pulmonary cavities, 【초록키워드】 Treatment, Intravenous immunoglobulin, antibody, children, Diagnosis, lung, C-reactive protein, CRP, tomography, ferritin, procalcitonin, lactate dehydrogenase, MIS-C, Infant, Pregnancy, Culture, COVID-19 infection, Chest, Fever, Thromboembolism, Evidence, hyperinflammatory state, Inflammatory, leucocyte, lesion, syndrome, thromboembolic complications, positive, nodule, MIS, polymerase chain, evaluated, elevated, treated, fast breathing, resolution of symptoms, thromboembolic complication, 【제목키워드】 Inflammatory, lung lesion, syndrome, cavitary, Potential,