Abstract
Objectives: We aimed to assess the level of prior SARS-CoV-2 infection in socially deprived neighbourhoods after the first wave of the pandemic, and to identify factors associated with seropositivity.
Design: A cross-sectional study.
Setting: Three socially deprived neighbourhoods of the city of Perpignan, in the south of France, where large settled Roma communities live.
Participants: People aged 6 years old or over, living in the study area. 700 people were included in the study using two-stage stratified sampling design.
Interventions: The study included a questionnaire and SARS-CoV-2 antibody testing by the Roche Elecsys immunoassay between 29 June and 17 July 2020.
Primary and secondary outcome measures: SARS-CoV-2 antibody seroprevalence was estimated from weighted data. Associated factors and reported symptoms were investigated using univariable and multivariable logistic regressions.
Results: The seroprevalence of anti-SARS-CoV-2 antibodies was 35.4% (95% CI 30.2% to 41.0%). People aged 15-64 years old had increased odds of being seropositive than those aged 65 years or over. Obese people had higher odds of being seropositive (adjusted OR (aOR)=2.0, 95% CI 1.1 to 3.8). The odds of being seropositive were higher in households with clinical COVID-19 cases (one case: aOR=2.5, 95% CI 1.3 to 5.0; several cases: aOR=6.9, 95% CI 3.1 to 15.2). In the neighbourhood with the highest measured seroprevalence, people living in a dwelling with one to two rooms had higher odds of being seropositive than those living in a four-room house (aOR=2.8, 95% CI 1.2 to 6.3). Working during the lockdown was associated with lower odds of being seropositive (aOR=0.2, 95% CI 0.03 to 1.0).
Conclusion: Transmission of SARS-COV-2 in this vulnerable population was very high during the COVID-19 pandemic’s first wave. Our results highlight the need to strengthen and adapt preventive measures taking into account all social determinants of health, especially housing conditions.
Keywords: COVID-19; epidemiology; public health.
【저자키워드】 COVID-19, public health, Epidemiology, 【초록키워드】 public health, pandemic, lockdown, cross-sectional, SARS-COV-2 infection, COVID-19 pandemic, immunoassay, Health, SARS-CoV-2 antibody, anti-SARS-CoV-2 antibody, Community, France, Roche, First wave, questionnaire, seropositive, SARS-CoV-2 antibody testing, preventive measure, Factor, 95% CI, COVID-19 case, secondary outcome, working, logistic regressions, highlight, multivariable, highest, identify, investigated, adjusted, conditions, stratified, Elecsy, higher odd, reported symptom, social determinant, univariable, 【제목키워드】 cross-sectional, COVID-19 pandemic, Seroprevalence, anti-SARS-CoV-2 antibody, First wave,