Abstract
Severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection in children and adolescents primarily causes mild or asymptomatic coronavirus disease 2019 (COVID-19), and severe illness is mainly associated with comorbidities. However, the worldwide prevalence of COVID-19 in this population is only 1%-2%. In Mexico, the prevalence of COVID-19 in children has increased to 10%. As serology-based studies are scarce, we analyzed the clinical features and serological response (SARS-CoV-2 structural proteins) of children and adolescents who visited the Hospital Infantil de México Federico Gómez (October 2020-March 2021). The majority were 9-year-old children without comorbidities who were treated as outpatients and had mild-to-moderate illness. Children aged 6-10 years and adolescents aged 11-15 years had the maximum number of symptoms, including those with obesity. Nevertheless, children with comorbidities such as immunosuppression, leukemia, and obesity exhibited the lowest antibody response, whereas those aged 1-5 years with heart disease had the highest levels of antibodies. The SARS-CoV-2 spike receptor-binding domain-localized peptides and M and E proteins had the best antibody response. In conclusion, Mexican children and adolescents with COVID-19 represent a heterogeneous population, and comorbidities play an important role in the antibody response against SARS-CoV-2 infection.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, SARS-COV-2 infection, children, obesity, Antibody Response, Infection, Comorbidities, peptide, Immunosuppression, Comorbidity, E protein, Asymptomatic, Mild, structural proteins, disease, leukemia, clinical feature, SARS-CoV-2 spike, serological response, Outpatient, Mild-to-moderate, acute respiratory syndrome, heterogeneous population, levels of antibodies, lowest, highest, analyzed, exhibited, treated, majority, cause, the antibody response, number of symptoms, prevalence of COVID-19, with COVID-19, 【제목키워드】 coronavirus disease, serology, children, clinical, feature,