Abstract
Objective: To evaluate the correlation of maternal and cord blood levels of SARS-CoV-2 antibodies in pregnant women immunized against COVID-19.
Methods: A prospective cohort study was performed of pregnant women who delivered at a single university affiliated tertiary medical center. Women who received the COVID-19 vaccine (BNT162b2 Pfizer©) were approached. The correlation between levels of maternal sera and umbilical cord SARS-CoV-2 specific IgG was assessed.
Results: Overall, 58 women were included; of them, 19 had received a single dose and 39 received two doses of the COVID-19 vaccine. Positive levels of umbilical cord IgG were found in 13/19 (68.4%) and 38/39 (97.4%) women after the administration of a single dose and two doses of the vaccine, respectively. The levels of SARS-CoV-2 IgG antibodies in the maternal sera of vaccinated women were positively correlated to their respective concentrations in cord blood sera (ρ = 0.857; R 2 linear = 0.719; P < 0.001). Thirteen days after vaccination, the ratio of maternal-to-umbilical cord anti Spike IgG antibodies was approximately 1, indicating relatively similar levels in maternal and cord sera.
Conclusion: After the SARS-CoV-2 vaccine, levels of maternal and cord blood antibodies were positively correlated, especially when tested after 13 days following administration of the first dose of the vaccine.
Keywords: SARS-COV-2; antibodies; cord blood; vaccination.
【저자키워드】 antibodies, SARS-CoV-2, vaccination, Cord blood, 【초록키워드】 COVID-19, IgG, Vaccine, COVID-19 vaccine, vaccination, spike, antibody, prospective cohort study, BNT162b2, pregnant women, IgG antibody, SARS-CoV-2 antibody, SARS-CoV-2 IgG antibody, sera, women, correlation, Blood, single dose, Blood level, administration, Concentration, dose, first dose, immunized, tested, evaluate, linear, was performed, the vaccine, R 2, positively correlated, the SARS-CoV-2, umbilical, 【제목키워드】 antibody, Cord blood, Blood, association,