Abstract
Data regarding antibody responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in patients infected with COVID-19 are not yet available. In this study, we aimed to evaluate serum antibody responses in patients regardless of the outcome. We measured the circulating immunoglobulin G (IgG) antibody levels in 60 subjects with a certified history of SARS-CoV-2 infection by using immunoenzymatic, chemiluminescent, and Neutralization assays. Half patients had a severe infection, the other half were pauci-symptomatic. We analyzed their antibody response to see the trend of the humoral response. Our results showed a significant difference in circulating IgG level among the two groups. The neutralizing antibody response against SARS-CoV-2 was significantly higher among those who had severe disease. Furthermore, ten subjects from each group were screened twice, and a declining antibody trend was observed in pauci-symptomatic individuals. These findings provide evidence that humoral immunity against SARS-CoV-2 in pauci-symptomatic people is weak and may not be long-lasting. This may have implications for immunity strategy and prevention, since it is still not clear whether a time-dependent decrease of both circulating and neutralizing antibodies to nonprotective levels could occur in a longer time span and whether potential vaccines are able to induce a herd immunity and a durable response.
Keywords: coronavirus; humoral immunity; neutralization.
【저자키워드】 coronavirus, neutralization, Humoral immunity, 【초록키워드】 neutralizing antibody, SARS-CoV-2, IgG, Severe infection, Vaccine, Immunity, antibody, neutralization, SARS-COV-2 infection, Antibody Response, outcome, Immunoglobulin, Patient, Neutralizing antibody response, Coronavirus-2, Evidence, severe disease, humoral, acute respiratory syndrome, significant difference, two groups, subject, pauci-symptomatic, circulating, implication, decrease, analyzed, evaluate, assays, screened, occur, long-lasting, induce, significantly higher, individuals, serum antibody response, declining, infected with COVID-19, 【제목키워드】 SARS-CoV-2, Clinical outcome, infected patient,