Abstract
We have utilised the transcriptional response of lung epithelial cells following infection by the original Severe Acute Respiratory Syndrome coronavirus (SARS) to identify repurposable drugs for COVID-19. Drugs best able to recapitulate the infection profile are highly enriched for antiviral activity. Nine of these have been tested against SARS-2 and found to potently antagonise SARS-2 infection/replication, with a number now being considered for clinical trials. It is hoped that this approach may serve to broaden the spectrum of approved drugs that should be further assessed as potential anti-COVID-19 agents and may help elucidate how this seemingly disparate collection of drugs are able to inhibit SARS-2 infection/replication.
Keywords: COVID-19; Gene expression; Repurposing.
【저자키워드】 COVID-19, Gene Expression, repurposing., 【초록키워드】 coronavirus, Infection, clinical trials, repurposing, drug, antiviral activity, severe acute respiratory syndrome Coronavirus, approved drugs, Replication, epithelial cells, respiratory, Spectrum, Lung epithelial cells, best, approved drug, acute respiratory syndrome coronavirus, help, respiratory syndrome coronavirus, transcriptional response, approach, tested, identify, inhibit, disparate, lung epithelial cell, utilised,