Abstract
Objective: To describe outcomes associated with monoclonal antibody use in pregnant persons with mild-to-moderate coronavirus disease 2019 (COVID-19).
Methods: We present a retrospective case series of pregnant patients who received anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibody infusions at a single center from April 1, 2021, through October 16, 2021. Pregnant patients who had a positive SARS-CoV-2 polymerase chain reaction (PCR) test result and mild-to-moderate COVID-19 symptoms were eligible for monoclonal antibody infusion. Exclusion criteria for administration included need for supplemental oxygen, hospitalization due to COVID-19, and positive SARS-CoV-2 PCR test result more than 7 days before screening. All patients received either bamlanivimab plus etesevimab or casirivimab plus imdevimab based on availability and dosing instructions of the product and emerging resistance patterns in the community.
Results: During the study period, monoclonal antibody infusions were administered to 450 individuals at our institution, of whom 15 were pregnant. Of the 15 pregnant persons receiving monoclonal antibody, six (40%) had full-vaccination status at the time of infusion. Two individuals (13%, CI 0-31%) experienced systemic reactions during the infusion, both resulting in temporary changes in the fetal heart rate tracing that recovered with maternal and intrauterine resuscitative efforts. One patient delivered after infusion for worsening maternal and fetal status; the remainder of the patients did not require admission for COVID-19.
Conclusion: In this case series, pregnant persons who received anti-SARS-CoV-2 monoclonal antibody infusions had generally favorable outcomes.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, Hospitalization, monoclonal antibody, outcome, anti-SARS-CoV-2, outcomes, Case series, PCR, etesevimab, Patient, Community, Admission, retrospective, administration, pregnant, Mild-to-moderate, criteria, COVID-19 symptom, supplemental oxygen, acute respiratory syndrome, systemic reaction, individual, one patient, study period, worsening, single center, positive, positive SARS-CoV-2 PCR, Administered, polymerase chain, resulting, the patient, receiving, case sery, changes in, fetal, eligible, pregnant patient, 【제목키워드】 COVID-19, Sery,