Abstract
Background: There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n = 14), symptomatic/nonpneumonic (n = 42), and pneumonic (n = 41) patients.
Results: The anti-SARS-CoV-2 immunoglobulin class G and neutralizing antibody (NAb) titers lasted until 6 months after diagnosis, with positivity rates of 66.7% and 86.9%, respectively. Older age, prolonged viral shedding, and accompanying pneumonia were more frequently found in patients with sustained humoral immunity. Severe acute respiratory syndrome coronavirus 2-specific T-cell response was strongly observed in pneumonic patients and prominent in individuals with sustained humoral immunity.
Conclusions: In conclusion, most (>85%) patients carry NAb until 6 months after diagnosis of SARS-CoV-2 infection, providing insights for establishing vaccination strategies against COVID-19.
Keywords: COVID-19; SARS-CoV-2; cellular immunity; humoral immunity; longevity.
【저자키워드】 COVID-19, SARS-CoV-2, Humoral immunity, cellular immunity, Longevity, 【초록키워드】 coronavirus disease, neutralizing antibody, coronavirus, Immunity, Pneumonia, T-cell Response, Infection, Diagnosis, anti-SARS-CoV-2, Asymptomatic, Immunoglobulin, Patient, age, prolonged viral shedding, patients, Clinical severity, cellular, Vaccination strategy, humoral, acute respiratory syndrome, study population, individual, evaluate, sustained, diagnosis of SARS-CoV-2, 【제목키워드】 coronavirus 2, clinical, response, respiratory, assessment, longitudinal, Month,